We perform genetic, microbiome and metabolome studies in monogenic diabetes, childhood obesity, Inuit in Greenland and large-scale genetic epidemiology studies. We use national registers to identify families and cases with extreme phenotypes, and have initiated whole exome sequencing and large-scale studies of the oral microbiome in relation to cardiometabolic health and disease.
Our major aims are:
1) to define subsets of cases with cardiometabolic disease and define optimal preventive and curative strategies
2) to define health associated genetics and microbiomics
3) to obtain a deeper understanding of cardiometabolic dysfunction at the molecular, organ and whole body level applying deep phenotyping, various imaging technologies and omics profiling methods.