Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, University of Copenhagen
We perform genetic, microbiome and metabolome studies in monogenic diabetes, childhood obesity, Inuit in Greenland and large-scale genetic epidemiology studies. We use national registers to identify families and cases with extreme phenotypes, and have initiated whole exome sequencing and large-scale studies of the oral microbiome in relation to cardiometabolic health and disease.
Our major aims are:
1) to define subsets of cases with cardiometabolic disease and define optimal preventive and curative strategies
2) to define health associated genetics and microbiomics
3) to obtain a deeper understanding of cardiometabolic dysfunction at the molecular, organ and whole body level applying deep phenotyping, various imaging technologies and omics profiling methods.