Rajat Gupta
Assistant professor
Novo Nordisk Foundation Center for Protein Research
Biography
DNA damage presents a major threat to genome stability, and cells have therefore evolved elegant mechanisms, collectively referred to as the DNA damage response (DDR), to protect their genome integrity . We combine CRISPR-based genome editing , APEX-based proximity labeling , and quantitative mass spectrometry to survey protein networks in the neighborhood of the endogenously expressed DDR factors. This allows us to map their interaction landscape in the native environment, revealing new insights into the global DDR networks.
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