Torben Heick Jensen
The regulation and fidelity of gene expression is of paramount importance for the maintenance and differentiation of all living organisms. Our laboratory studies the production and turnover of RNA in eukaryotic cells (S. cerevisiae, mouse and human) and its contribution to gene expression regulation at the post-transcriptional level. A main focus of the laboratory is to understand the molecular principles dictating the sorting of newly transcribed RNA into a productive pathway involving its packaging with protein and cellular transport vs. a destructive pathway leading to RNA turnover.
Laboratory efforts can roughly be divided into four research topics:
· Delineation of nuclear human RNA decay pathways and their regulatory capacities
· Regulatory capacities of pervasive transcription
· Shaping of human transcriptomes by nonsense-mediated decay (NMD)
· Relationships between RNA synthesis and decay in S. cerevisiae
From 2005-2015 Torben Heick Jensen was heading the Danish National Research Foundation-funded ‘Centre for mRNP Biogenesis and Metabolism’. These, and other, efforts are now continued via funding from the European Research Council (ERC), the Danish Council for Independent Research, the Novo Nordisk foundation, the Lundbeck Foundation and the Danish Cancer Society.