Redox Signaling and Oxidative Stress, Danish Cancer Society
We are interested in understanding the molecular mechanisms, which are induced in cancer cells as adaptive responses to stressful conditions (i.e., oxidative stress) providing therapy resistance, capability to migrate and invade distant tissues. In this context, our main focus is to unveil how:
Oxidative stress modifies protein structure-function (redox signaling) and affects cancer growth
Redox signaling cross talks with other signaling networks (e.g. phosphorylation or ubiquitination)
Redox signaling contributes to processes sustaining malignancy (e.g. autophagy and epithelial-mesenchymal transition)
Cancer is characterized by heterogeneous molecular mechanisms and signaling pathways, which are induced by adaptive responses to stressful conditions (e.g. oxidative stress) and lead to the selection of cells characterized by therapy resistance, capability to migrate and invade distant tissues.