The Nissen group investigates the structure and molecular mechanisms of membrane transport processes, receptors, and biomembrane ultrastructure. Activities are mainly focused on using cryo-electron microscopy (Cryo-EM), protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and cryo-electron tomography.
A major topic of research interest is membrane transporters and receptors involved with neurological and psychiatric disorders, e.g. P-type ATPase that include ion pumps and lipid flippases, but also sodium-dependent amino acid, neurotransmitter transporters, and insulin receptor signaling are studied, as well as supramolecular structures of neuronal membranes addressing cooperative networks governing e.g. action potentials and synaptic functions. Studies also include structure-based drug discovery and protein engineering.