Biotech Research & Innovation Centre BRIC, University of Copenhagen
We study how protein kinase cascades activated by extracellular signaling molecules regulate normal cell behaviour and how their dysregulation may cause cancer and other diseases. We use functional genetics to unravel the genes, mutations and mechanisms that cause human cancer and to identify novel anti-cancer drug targets. Our research takes outset in the myriad of genes found mutated by cancer genome sequencing. We develop genetic cell and mouse models harboring the patient mutations in order to test the genes as bona fide novel oncogenes or tumor suppressors. We use our genetic models to elucidate new cancer mechanisms and test drivers as drug targets.