My main research interest is the effect of host responses on bacterial susceptibility to antibiotics. It has become clear that host cells may cause limited oxygen availability in bacterial infections, whereby a stratified physiology occurs, that is associated with increased tolerance of antibiotics.
I am currently investigating the effect of supplementation of O2 under hyperbaric pressure in combination with antibiotics on bacterial biofilm in order to increase the bactericidal activity of antibiotics. I conduct research studies with a primary focus on the interaction between infection and inflammation in patients with acute and chronic lung infection. I use my knowledge and establish methods in different patient groups to explore differences and similarities in bacterial physiology and treatment outcomes. The special area of interest is pneumonia.