The research concerns identification and functional characterization of genes involved in complex disorders with a main focus on psychiatric disorders.
Large sample sets including thousands of individuals from national biobanks, multiplex families, trios, twins and isolated populations are studied, using cutting edge approaches such as GWAS, whole genome and exome sequencing. Epigenetic mechanisms and gene-environment interplays are also important aspects of the studies performed.
The massive data generated in these studies are analysed by agnostic as well as hypothesis driven approaches trying to integrate the different layers of information, using a range of bioinformatic, genetic epidemiologic and statistical genetic methodologies, some of which are developed by the group.
The biological function and pathogenic mechanisms of identified disease associated genes are investigated at the molecular level, in cell models and in genetically modified animal models.
The overall aim is to increase the aetiological and pathophysiological understanding in order to provide a basis for better diagnosis, treatment and prevention of the disabling and severe disorders investigated.